Effect of elapsed time after discontinuation of L-dopa on rotarod performance. PITx3(−/−) mice were trained with L-dopa for 7 sessions (sessions 1–7). One group was tested without treatment 3 days following discontinuation of L-dopa (red circles, sessions 8 –11), another group was tested 10 days after L-dopa discontinuation (blue circles, sessions 8 –11), and a final group was tested with L-dopa treatment after a 10-day suspension of L-dopa (black circles, sessions 8 –11). (A) Latency to fall in each trial. (B) Average latency to fall during each session. n = 12 for the 3-day interval group; n = 6 for 10-day interval groups.