Table 2.
Minimally Adjusted Random-Effects Logistic Regression Models of the Odds of High Depressive Symptoms for Each Hormonea
| OR (95% CI)
|
||
|---|---|---|
| Hormoneb | Concurrent Hormone | Change in Hormone Levels From Baseline |
| logE2 | 1.00 (0.93–1.06) | 1.01 (0.94–1.08) |
| logFSH | 1.05 (0.97–1.13) | 1.04 (0.85–1.14) |
| logT | 1.19 (1.05–1.36)c | 1.24 (1.06–1.46)c |
| logDHEA-S | 0.96 (0.86–1.08) | 1.09 (0.92–1.29) |
| logFTI | 1.11 (1.02–1.20)d | 1.14 (1.03–1.27)d |
| logFEI | 1.00 (0.94–1.06) | 1.02 (0.96–1.10) |
Abbreviations: CES-D, Center for Epidemiological Studies Depression Scale; CI, confidence interval; DHEA-S, dehydroepiandrosterone sulfate; E2, estradiol; FSH, follicle-stimulating hormone; FEI, free estradiol index; FTI, free testosterone index; OR, odds ratio; T, testosterone.
High depressive symptoms are indicated by a CES-D score of 16 or higher. Each model is adjusted for race/ethnicity, study site, baseline age, and aging/time since baseline (n=3296); the change in hormone models also includes the baseline value of that particular hormone (n=2882). Concurrent hormone uses data from baseline through visit 8; change in hormone levels from baseline uses data from visits 1 through 8.
Log indicates natural logarithm transformation (ie, base e).
P<.01.
P<.05.