Table 1.
Inhibition of AChE by Cyclophostin and Related Compounds.
| no. | IC50 | KI | k2, min−1 | k−2, min−1 |
|---|---|---|---|---|
| 5a | 30 µM | 140 ± 60 µM | 0.4 ± 0.1 | 4e-3 |
| 5b | 3 µM | 24 ± 6.0 µM | 0.3 ± 0.06 | 0.02 |
| 1 | 45 nM | 140 ± 72 nM | 0.7 ± 0.02 | 0 |
| 17 | 40 nM | 210 ± 140 nM | 0.9 ± 0.5 | 0 |
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