Table 4.
Genomic studies of outcome in classical Hodgkin lymphoma
| Technique | Number of cases | Material | HRS microdissection | HRS cell-related gene signatures associated with worse outcome | ME-related gene signatures associated with worse outcome | Reference |
|---|---|---|---|---|---|---|
| GEP | 29 | Paraffin-embedded tissue | No | Cell cycle | Macrophages, T cells | [78] |
| RT-PCR array | 52 | Paraffin-embedded tissue | No | G2/M transition, G1 phase, chaperone pathway, MAPK pathway, apoptosis | Monocytes, macrophages, T cells | [76] |
| GEP | 282 | Paraffin-embedded tissue | No | Cell cycle, apoptosis, IFR4 | Macrophages | [77] |
| GEP | 63 | Frozen fresh tissue | No | BCR signalling, apoptosis, cell metabolism | Stroma remodeling | [49] |
| GEP | 130 | Frozen fresh tissue | No | HRS cell related genes | Macrophages, angiogenic cells, monocytes | [68] |
| aCGH | 53 | Frozen fresh tissue | Yes | Gains of 16p (ABCC1) | NA | [81] |
| aCGH | 27 | Paraffin-embedded tissue | Yes | 4q27 loss (IL2/IL21), 17p12 loss, 19q13.3 gain (BCL3/RELB) | NA | [82] |
aCGH, array comparative genomic hybridization; BCR, B-cell receptor; GEP, gene-expression profile; HRS, Hodgkin and Reed-Sternberg (cell); MAPK, mitogen activated protein kinase; ME, microenvironment; SNP, single-nucleotide polymorphism.