Skip to main content
. Author manuscript; available in PMC: 2011 Jul 5.
Published in final edited form as: Stem Cells. 2010 Jul;28(7):1281–1291. doi: 10.1002/stem.447

Figure 4.

Figure 4

Affected protein chaperoning genes organize into a calreticulin inclusive network. (A): Calreticulin-impacted chaperoning genes were hierarchically clustered according to Pearson correlation. (B): Taqman validation of randomly selected chaperoning molecules, suppressor of tumorigenicity 13 (St13) and prefoldin six (Pfdn6). (C): Genes were downregulated (green) and organized into a network of associated modules. Clockwise from left: Discrete curated interaction of Exosc6 and Wbscr18 (boxed in dashed line); TRiC/ CCT module with Cct2 Cct3, and Cct7 downregulated (outlined in purple); prefoldin subnetwork showing downregulation in Pfdn5 and Pfdn6 (circled in blue); central network that integrated nonmodular genes (orange boxes); and the Tomm complex with affected genes highlighted in green (outlined in red). Abbreviation: WT, wild type.