Fig. 4.

Decreased SynGAP expression results in enhanced phosphorylated (p)-ERK and transient receptor potential cation channel subfamily V member 1 (TRPV1) expression. A: representative blot from DRG protein extracts from WT or SynGAP^+/− mice probed for p-ERK and total ERK (t ERK). Each column represents the density of the immunoreactive p-ERK band normalized to the total ERK band (mean ± SEM for 5 independent experiments). B: a representative blot from DRG protein extracts from WT or SynGAP^+/− mice probed for TRPV1 and actin. Each column represents the density of the immunoreactive TRPV1 band normalized to the actin band. *Statistically significant difference between genotypes using Student's t-test.