Fig. 6.

Mechanical and thermal hypernociception induced by intraplantar injection of capsaicin in WT and SynGAP^+/− mice. Time course of mechanical nociceptive responses (left panels) or thermal nociceptive responses (right panels) in vehicle-treated (A) or capsaicin-treated (B–D) WT (■) or SynGAP^+/− (○) mice. Each point is the mean ± SEM for withdrawal in grams of force (left panels) or threshold for withdrawal latency in seconds (right panels) of 4 animals of each genotype/group. *Statistically significant difference (P < 0.05) between genotypes; #statistically significant difference (p <0.05) between before and after intraplantar capsaicin injection using 2-way repeated-measures ANOVA, followed by Bonferroni post-hoc analysis.