Table 1.

Maternal drug feeding suppresses seizure in sda larvae

Genotype	Mean Recovery Time, s	n
WT	31.2 ± 3.8*	40
WT + DMSO	86.5 ± 3.8*	15
WT + PHY	187 ± 26.6*	20
sda	203.5 ± 18†	40
sda + DMSO	267.3 ± 41.4†‡	15
sda + PHY	86.5 ± 12.0‡	20

Values are means ± SD; n, no. of flies tested. Feeding phenytoin (PHY; 0.4 mg/ml) to gravid females resulted in progeny that did not display increased seizures. Progeny were electroshocked at the third instar and were never exposed to PHY other than what might have been transferred to them from the adult female. Wild-type (WT) and slamdance (sda) larvae fed vehicle only (DMSO) exhibited increased mean recovery times, indicating that DMSO has a proconvulsive effect. WT larvae fed PHY showed a greatly increased mean recovery time, indicating that this compound is proconvulsive when fed to normal nonbang-sensitive animals (see results for more detail). Pair-wise significance is indicated as follows:

^*‡P ≤ 0.01 and

^†P ≤ 0.05.