Table 1.
Demographic and Clinical Characteristics by Treatment Arm at Baseline.
| Baseline Characteristic1 | Escitalopram (N =104) | Placebo (N=101) | ||
|---|---|---|---|---|
| N | % | N | % | |
| Age at screening, mean (SD) | 53.45 (4.20) | 54.36 (3.86) | ||
| 42 – 49 | 16 | 15.4 | 8 | 7.9 |
| 50 – 54 | 48 | 46.2 | 47 | 46.5 |
| 55 – 59 | 30 | 28.8 | 36 | 35.6 |
| 60 – 62 | 10 | 9.6 | 10 | 9.9 |
| Race | ||||
| White | 53 | 51.0 | 49 | 48.5 |
| African American | 47 | 45.2 | 48 | 47.5 |
| Other | 4 | 3.8 | 4 | 4.0 |
| Education | ||||
| ≤ High school diploma or GED | 15 | 14.4 | 23 | 22.8 |
| School/training after high school | 46 | 44.2 | 41 | 40.6 |
| College graduate | 43 | 41.3 | 37 | 36.6 |
| Employment status | ||||
| Retired or no employment | 23 | 22.1 | 28 | 27.7 |
| Homemaker | 9 | 8.7 | 6 | 5.9 |
| Full-time | 48 | 46.2 | 46 | 45.5 |
| Part-time | 19 | 18.3 | 16 | 15.8 |
| Other | 5 | 4.8 | 5 | 5.0 |
| Marital Status | ||||
| Never married | 18 | 17.3 | 13 | 12.9 |
| Divorced | 18 | 17.3 | 26 | 25.7 |
| Widowed | 4 | 3.8 | 6 | 5.9 |
| Married or living with partner | 64 | 61.5 | 56 | 55.4 |
| Smoking | ||||
| Never | 53 | 51.0 | 46 | 45.5 |
| Past | 30 | 28.8 | 29 | 28.7 |
| Current | 21 | 20.2 | 26 | 25.7 |
| Alcohol use (drinks/week) | ||||
| 0 | 41 | 39.4 | 41 | 40.6 |
| 1–<7 | 51 | 49.0 | 41 | 40.6 |
| 7+ | 12 | 11.5 | 17 | 16.8 |
| BMI (m/kg2), mean (SD) | 28.58 (6.59) | 29.70 (6.42) | ||
| <25 | 32 | 30.8 | 22 | 21.8 |
| 25 – <30 | 34 | 32.7 | 38 | 37.6 |
| ≥ 30 | 38 | 36.5 | 40 | 39.6 |
| Menopause status | ||||
| Post-menopause | 84 | 80.8 | 83 | 82.2 |
| Late Transition | 17 | 16.3 | 15 | 14.9 |
| Early Transition | 3 | 2.9 | 3 | 3.0 |
| Hysterectomy | ||||
| Hysterectomy | 13 | 13 | 13 | 13 |
| Hysterectomy + oophorectomy | 11 | 10 | 8 | 8 |
| Oophorectomy only | 3 | 3 | 1 | 1 |
| None | 77 | 74 | 78 | 78 |
| Self-reported health | ||||
| Excellent | 18 | 17.3 | 13 | 12.9 |
| Very Good | 41 | 39.4 | 40 | 39.6 |
| Good | 36 | 34.6 | 37 | 36.6 |
| Fair | 7 | 6.7 | 11 | 10.9 |
| Poor | 1 | 1.0 | 0 | 0.0 |
| PHQ-9 Depression score, mean (SD) | 3.24 (3.06) | 2.94 (3.24) | ||
| No depression (0–4) | 76 | 73.1 | 77 | 76.2 |
| Mild depression (5–9) | 24 | 23.1 | 15 | 14.9 |
| Moderate+ depression (10–13) | 4 | 3.8 | 8 | 7.9 |
| GAD-7 Anxiety score, mean (SD) | 2.50 (3.34) | 2.19 (3.33) | ||
| No anxiety (0–4) | 80 | 76.9 | 82 | 81.2 |
| Mild anxiety (5–9) | 19 | 18.3 | 15 | 14.9 |
| Moderate+ anxiety (10–19) | 5 | 4.8 | 4 | 4.0 |
1
There are no significant differences between the 2 study groups as tested by t test or chi-square.