Figure 4.
Kinetics of transgene expression. Time course of luciferase transgene expression levels following intravenous administration of adeno-associated virus serotype 9 (AAV9) and AAV9.45 vectors (5 × 1010 vg/mouse) in (a) heart and (b) liver. Luciferase expression levels determined at 1 week (gray bar), 2 weeks (white bar), and 4 weeks (dark gray bar) were normalized for total tissue protein concentration and data represented as relative light units. All experiments were carried out in triplicate. Error bars represent standard deviation.