Figure 1.
Comparison of the oncolytic effects of LC16m8Δ and LC16mO in mice bearing intraperitoneal xenografts. (a) BxPC-3 cells stably expressing luciferase (5 × 106 cells) were intraperitoneally injected into female severe combined immunodeficiency mice on day 0. Seven days after tumor implantation, the mice were intraperitoneally injected with a single dose of LC16mO or LC16m8Δ (1 × 107 plaque-forming unit/mouse). (b) In vivo tumor growth was monitored noninvasively by bioluminescence imaging after intraperitoneal administration of -luciferin on days 4, 18, and 29. Quantification of the bioluminescence signals (photons/s) in the imaging data from days 4 and 18 in a. The data are presented as mean ± SD (n = 4).