Effect of 8-wk consumption of a HF diet on adiposity and circulating leptin levels. A–C: weight of epididymal (A), retroperitoneal (B), and mesenteric fat pads (C) collected from left side of LF, DR, and DIO rats after 8 wk on respective diets. D: combined weight of collected adipose tissue as percentage of body weight (%BW). E: circulating leptin levels in fasted LF, DR, and DIO rats after 8 wk on respective diets. a,bSignificant differences between groups with different letters.