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. Author manuscript; available in PMC: 2011 Jul 5.
Published in final edited form as: Epilepsia. 1999 Sep;40(9):1190–1197. doi: 10.1111/j.1528-1157.1999.tb00847.x

FIG. 1.

FIG. 1

VGB-induced reduction of GABA-synthesizing enzyme (GAD-67) abundance, consistent with elevation of GABA levels. Low-power view of immunoreactivity for glutamicacid-decarboxylase isoform GAD-67 in infant rat neocortex, showing the effect of VGB on GAD expression. A, B: From homologous portions of the parietal cortex of a 10-day-old control rat and its VGB-treated littermate, respectively. GAD-67 immunoreactive neurons are seen in all six cortical layers–indicated by roman numerals–of the control section (A). Abundance of GAD-67–immunolabeled cell bodies is substantially reduced after VGB treatment (B). WM, white matter. (Original magnification, ×100).