. Author manuscript; available in PMC: 2011 Jul 5.

Published in final edited form as: Brain Res Dev Brain Res. 1998 Nov 1;111(1):119–128. doi: 10.1016/s0165-3806(98)00130-8

Table 3.

Determination of threshold convulsant dose of KA in the 10 day old rat

Dose (mg/kg)	N	Latency (min)	Duration (min)
0.2	8	72.1 ± 5.5^a	18.8 ± 3.2^a
0.3	12	28.1 ± 2.5	43.3 ± 10.6
0.8	3	23.0 ± 0.6	120.0 ± 2.8
1.0	8	20.6 ± 3.3	160.2 ± 3.2

Only 6 of 8 rats had seizures.

KA was administered intraperitoneally to infant rats, while controls (n = 8) received equal volumes of vehicle, to determine a threshold dose. Latency to the onset of limbic automatisms and the duration of seizures were recorded. All values are means ± S.E.M. KA = kainic acid.