. Author manuscript; available in PMC: 2011 Jul 5.

Published in final edited form as: Brain Res Dev Brain Res. 1998 Nov 1;111(1):119–128. doi: 10.1016/s0165-3806(98)00130-8

Table 4.

Interaction of threshold doses of CRH and KA

Treatment	N	Seizure duration (min)	Behavioral features
KA	8	28.1 ± 3.8^a	oral automatisms, groom, scratch
CRH + KA	9	63.7 ± 8.2	WDS, severe automatisms
CRH	8	62.5 ± 6.0	oral automatisms, rare WDS

Ten day old rat pups were given KA (0.2 mg/kg) intraperitoneally alone or followed 30 min later by intracerebroventricular infusion of 22.5–30 × 10⁻¹² mole of CRH (see Section 2). A third group received CRH only. Control groups carrying cannula alone or receiving vehicle only did not have any abnormal behavior.

Indicates significant difference from the other two groups (p < 0.05) determined by one-way ANOVA analysis.

CRH = corticotropin releasing hormone; KA = kainic acid; WD = wet dog shakes.