Table 1.

Rate of psychiatric disorders in our cohort of children with 22q11DS (N = 72), compared to the rate in the general pediatric population, illustrating the high rate of psychopathology in these children.

DSM-IV Diagnosis	Number	Percentage	Estimated Percentage in Pediatric Population*
Social Phobia	4	5.6	1
Separation Anxiety	5	6.9	5
Specific Phobia	27	37.5	5
Panic Disorder	1	1.4	< 1
Agoraphobia	1	1.4	1
Generalized Anxiety Disorder	4	5.6	4 to 7
Obsessive Compulsive Disorder	7	9.7	1–2
Post-Traumatic Stress Disorder	1	1.4	2
Any Anxiety Disorder	33	45.8	13
Attention-Deficit Hyperactivity Disorder	31	43.1	5–7
Oppositional Defiant Disorder	10	13.9	10
Major Depressive Disorder	2	2.8	2–8
Dysthymia	0	0	1
Schizophrenia Spectrum Disorder#	1	1.4	1
Bipolar Disorder	0	0	0.1
Any DSM-IV Diagnosis	48	66.7	11–21
No DSM-IV Diagnosis	23	31.9	79–89
One DSM-IV Diagnosis	28	38.9	---
Two or More DSM-IV Diagnoses	21	29.2	---

^*National Institutes of Mental Health statistics and National Health and Nutrition Examination Survey, (Merikangas et al.; Costello et al., 1996)

^#It is to be noted that the rate of schizophrenia spectrum disorders is lower in our cohort than expected, since all of our subjects are in an age range where high rates of schizophrenia are not anticipated.