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. 2011 Apr 13;301(1):F118–F124. doi: 10.1152/ajprenal.00534.2010

Fig. 7.

Fig. 7.

Inhibition of DNM decreases nitrite production. A: nitrite production from COS7 cells overexpressing NOS1α + DNM2 was inhibited by the dynamin inhibitor dynasore in the presence and absence of ionomycin. Statistical analysis by 2-way ANOVA. *P < 0.05 compared with 3 μM ionomycin. †P < 0.05 compared with 0 μM dynasore. B: nitrite production from control (untransfected) mIMCD-3 cells or the dominant negative DNM2-K44A in the presence and absence of ionomycin. Statistical analysis by 2-way ANOVA. *P < 0.05 compared with 3 μM ionomycin. C: nitrite production by freshly isolated rat IMCDs was abolished by incubation with 80 μM dynasore for 1 h. ND, not detected.