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. 2011 Apr 20;301(1):F125–F133. doi: 10.1152/ajprenal.00041.2011

Fig. 3.

Fig. 3.

Chronic NIC exposure increases oxidative stress in the kidney. A: expression of nitrotyrosine (NTyr) in kidney lysates from C57BL/6J mice that underwent renal IR injury was determined by Western blotting. One group received saccharine while the other NIC as described in materials and methods. B: densitometry of results from A. Values are means ± SD of NTyr/actin ratios; n = 4 (sham) and n = 8 (IR). *P < 0.05 compared with sham. #P < 0.05 compared with saccharine group. @P < 0.05 compared with the saccharine group. C: renal malondialdehyde (MDA) content of kidney lysates from C57BL/6J mice that underwent renal IR injury was determined by spectrophotometry as described in materials and methods. One group received saccharine while the other NIC as described in materials and methods. Values represent MDA content in nmol/mg protein and expressed as means ± SD; n = 4 (sham) and n = 8 (IR). *P < 0.05 compared with sham. #P < 0.05 compared with saccharine group. @P < 0.05 compared with saccharine group.

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