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. 2011 Apr 20;301(1):F125–F133. doi: 10.1152/ajprenal.00041.2011

Fig. 5.

Fig. 5.

Chronic NIC exposure exacerbates acute renal ischemia-induced phosphorylation of JNK and c-jun in the mouse kidney. A: levels of phospho-JNK and JNK in kidney lysates from C57BL/6J mice that underwent renal IR injury were determined by Western blotting. One group received saccharine while the other NIC as described in materials and methods. B: densitometry of results from A. Values are expressed as means ± SD of ratios of pJNK/JNK; n = 4 (sham) and n = 8 (IR). *P < 0.05 compared with sham. #P < 0.05 compared with saccharine group. @P < 0.05 compared with the saccharine group. C: levels of phospho-c-jun and actin were also determined as described in A. D: densitometry of results from C. Values are expressed as means ± SD of p-c-jun/actin ratios; n = 4 (sham) and n = 8 (IR). *P < 0.05 compared with sham. #P < 0.05 compared with saccharine group. @P < 0.05 compared with the saccharine group.

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