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Effect of 24-h treatment of embryonic day 19 fetal rat lung explants with nicotine, NNK, or NNA (1 × 10−11, 1 × 10−8, and 1 × 10−5 M) on BCL-2-to-Bax ratio (BCL-2/Bax). BCL-2/Bax decreased significantly with nicotine, NNK, or NNA treatment (*P < 0.05 vs. control; n = 3).
