Table 1.
Expression profile of IPF alveolar type II cells obtained by laser capture
| No Change in IPF Epi |
Lower in IPF Epi* |
Higher in IPF Epi* |
|||
|---|---|---|---|---|---|
| Gene Name | Fold Change | Gene Name | Fold Change | Gene Name | Fold Change |
| SFTPC | 2.5 | TGFBR3 | 0.49 | FoxG1 | 20000 |
| ECAD | 2.0 | Vimentin | 0.38 | GBX2 | 658 |
| MUC5AC | 1.8 | VEGFC | 0.35 | Filaggrin | 137 |
| Snail 1 | 1.7 | FLT4 | 0.32 | PITX1 | 113 |
| ITGβ6 | 1.6 | HBEGF | 0.31 | CNN1 | 69 |
| SFTPB | 1.4 | Epiregulin | 0.29 | POU2F2 | 45 |
| TGFBR2 | 0.93 | Integrin α5 | 0.27 | Smoothen | 31 |
| TGFBR1 | 0.84 | IRF1 | 0.19 | Collagen, type1 | 18 |
| Decorin | 0.79 | FGF1 | 0.10 | MMP7 | 8 |
| Caldesmin | 0.68 | MMP17 | 0.09 | α-SMA | 7 |
| SFTPA1 | 0.58 | CD69 | 0.07 | Integrin α3 | 4 |
| Fibronectin | 0.45 | PAI-1 | 0.04 | CDK 6 | 3 |
| SLUG | 0.27 | IL6 | 0.002 | ||
| CFTR | 0.09 | ENA78 | 0.002 | ||
*
Genes identified by Significance Analysis of Microarrays (SAM) analysis to be differentially expressed in idiopathic pulmonary fibrosis (IPF) epithelial cells (Epi).