Fig. 8.

Effect of TSP1 EGF-like repeats and EGFR ligands on transendothelial ¹⁴C-albumin flux. Postconfluent HMVEC-L monolayers were exposed for 6 h to increasing concentrations of recombinant TSP1 EGF-like repeats (A) or recombinant human EGF, TGF-α, or amphiregulin (B). Mean (± SE) pretreatment baseline transendothelial ¹⁴C-BSA flux is shown by the open bars. Each symbol represents mean (± SE) ¹⁴C-BSA flux in pmol/h immediately after 6-h exposures to increasing concentrations of the TSP1 EGF-like repeats (A) or EGFR ligands (B); n indicates number of monolayers studied and is indicated next to each symbol.