Fig. 3.

RGZ attenuates hypoxia-induced inhibition of alveolar development. A–D: representative photomicrographs (×100, hematoxylin and eosin stain; calibration bars = 250 μm) of lung sections from 14-day-old mice exposed to air (A and C), or hypoxia (B and D) in combination with either RGZ (C and D) or vehicle (A and B). Radial alveolar count (E) and mean linear intercept (F) of pups administered RGZ or vehicle at 14 days while exposed to air or hypoxia are shown, demonstrating a reduction in radial alveolar count and an increase in mean linear intercept with hypoxia, which are attenuated by RGZ (means ± SE; n = 6 mice/group; *P < 0.05 vs. corresponding air; #P < 0.05 vs. corresponding vehicle).