Fig. 6.
Summary of valve closure and opening tests for one lymphatic vessel. A, left axis: pressure gradient required for valve closure (Pout − Pin; ●) or opening (Pin − Pout; ○) plotted as a function of baseline pressure. Each point is the average ΔP (Pout − Pin) for 3 trials. Right axis: continuous pressure diameter relationship for the same vessel determined from a simultaneous Pin + Pout ramp from 0.2 to 20 cmH2O in Ca2+-free PSS after valve gating tests were completed; data were normalized to the passive diameter at 20 cmH2O. B: pressure gradient required for valve closure (Pout − Pin; ●) or opening (Pin − Pout; ○) plotted as a function of normalized diameter. All measurements were made in Ca2+-free PSS. All curve fits are power functions. D/Dmax, passive diameter/maximum passive diameter.