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. 2011 Apr 13;301(1):H98–H107. doi: 10.1152/ajpheart.00668.2010

Fig. 3.

Fig. 3.

MAPK and Smad2 activity with chemical inhibitors of the ERK and phosphatidylinositol 3-kinase (PI3K) pathways at 20 h of 10 dyn/cm2, average shear stress at 80 ± 5 mmHg, and exemplary Western blot lanes. Plot points and blot quantification was performed as in Fig. 1. A: ERK phosphorylation in the presence of 10 μmol/l PD98059. For 10 dyn/cm2 and 10 dyn/cm2 + PD98059: n = 3. B: L-psmad2 levels in the presence of 10 μmol/l PD98059. For 10 dyn/cm2, n = 4, and for 10 dyn/cm2 + PD98059: n = 3. C: L-psmad2 levels in the presence of 40 μmol/l LY294002 and 1 μmol/l PI-103. For 10 dyn/cm2, n = 3, for 10 dyn/cm2 + LY294002, n = 2, and for 10 dyn/cm2 + PI-103, n = 3. D: JNK phosphorylation in the presence of 1 μmol/l PI-103. For 10 dyn/cm2, n = 3, and for 10 dyn/cm2 + PI-103, n = 3. *P < 0.05; **P < 0.01; ‡P < 0.0001.