Table 1.

Final body weight, heart-to-body weight ratio, kidney-to-body weight ratio, and blood pressure values at the end of 6 wk of treatment

	SHRSP	SHRSP + DOX	WKY Rats	WKY Rats + DOX
Final body weight	261 ± 7	266 ± 4	265 ± 5	270 ± 6
Heart-to-body weight ratio	0.50 ± 0.02*	0.44 ± 0.01*†	0.32 ± 0.01	0.31 ± 0.01
Kidney-to-body weight ratio	0.97 ± 0.02*	1.00 ± 0.02*	0.67 ± 0.01	0.73 ± 0.01†‡
Systolic srterial pressure	184 ± 3	193 ± 3†	N/A	N/A
Diastolic arterial pressure	128 ± 2	135 ± 2†	N/A	N/A
Mean arterial pressure	156 ± 3	164 ± 2†	N/A	N/A
Heart rate	311 ± 5	321 ± 1†	N/A	N/A

Values are means ± SE. Data were analyzed by one-way ANOVA. DOX, doxycycline; N/A, not applicable.

^*P < 0.05, statistically different from normotensive Wystar Kyoto (WKY) rats;

^†P < 0.05, statistically different from untreated stroke-prone spontaneously hypertensive rats (SHRSP);

^‡P < 0.05, statistically different from untreated WKY rats.