Table 3.
Systemic hemodynamic responses
| Inflation |
Deflation |
|||||
|---|---|---|---|---|---|---|
| Baseline | Exercise (Control) | Nadir | Steady state | Acute | Steady state | |
| Protocol 1 | ||||||
| 20% MVC (no drug) | ||||||
| Mean arterial pressure, mmHg | 85 ± 5 | 91 ± 5* | 92 ± 4* | 93 ± 4* | 95 ± 4* | 94 ± 4* |
| Brachial artery pressure, mmHg | 84 ± 3† | 87 ± 2† | 56 ± 3*‡ | 75 ± 4†‡ | 89 ± 3† | 88 ± 2† |
| Heart rate, beats/min | 61 ± 2 | 61 ± 1 | 61 ± 1 | 62 ± 1 | 61 ± 1 | 60 ± 1 |
| Cardiac output, l/min | 5.5 ± 0.4 | 5.8 ± 0.5 | 6.0 ± 0.4* | 6.0 ± 0.5* | 5.9 ± 0.6 | 6.0 ± 0.6* |
| 20% MVC (Ketorolac) | ||||||
| Mean arterial pressure, mmHg | 85 ± 3 | 90 ± 3* | 91 ± 3* | 94 ± 3* | 94 ± 4* | 92 ± 3* |
| Brachial artery pressure, mmHg | 84 ± 2† | 86 ± 2† | 60 ± 4*‡ | 73 ± 5†‡ | 87 ± 3† | 87 ± 1† |
| Heart rate, beats/min | 60 ± 2 | 61 ± 2 | 61 ± 2 | 61 ± 2 | 61 ± 2 | 60 ± 1 |
| Cardiac output, l/min | 5.6 ± 0.5 | 5.8 ± 0.4 | 5.9 ± 0.4 | 6.0 ± 0.4* | 6.1 ± 0.5* | 6.0 ± 0.5* |
| 20% MVC (Ketorolac + l-NMMA) | ||||||
| Mean arterial pressure, mmHg | 87 ± 4 | 92 ± 4* | 95 ± 4* | 97 ± 4* | 97 ± 4* | 96 ± 3* |
| Brachial artery pressure, mmHg | 85 ± 3† | 87 ± 3† | 58 ± 4*†‡ | 74 ± 3*†‡ | 89 ± 3† | 88 ± 3† |
| Heart rate, beats/min | 58 ± 1 | 59 ± 1 | 58 ± 1 | 58 ± 1 | 58 ± 1 | 58 ± 1 |
| Cardiac output, l/min | 5.4 ± 0.4 | 5.6 ± 0.3 | 5.6 ± 0.3 | 5.6 ± 0.4 | 5.8 ± 0.3* | 5.9 ± 0.5* |
| Protocol 2 | ||||||
| 20% MVC (no drug) | ||||||
| Mean arterial pressure, mmHg | 87 ± 2 | 96 ± 4* | 97 ± 5* | 101 ± 5* | 101 ± 5*† | 99 ± 5* |
| Brachial artery pressure, mmHg | 84 ± 3† | 90 ± 4† | 65 ± 4*†‡ | 84 ± 5† | 92 ± 3*† | 93 ± 5*† |
| Heart rate, beats/min | 61 ± 2 | 62 ± 2 | 63 ± 2 | 62 ± 2 | 62 ± 2 | 62 ± 2 |
| Cardiac output, l/min | 5.5 ± 0.4 | 5.8 ± 0.3 | 6.0 ± 0.5* | 6.2 ± 0.4* | 6.2 ± 0.4* | 6.3 ± 0.4*‡ |
| 20% MVC (l-NMMA) | ||||||
| Mean arterial pressure, mmHg | 89 ± 3 | 97 ± 2* | 97 ± 2* | 101 ± 3* | 100 ± 3* | 101 ± 4* |
| Brachial artery pressure, mmHg | 87 ± 2† | 91 ± 3† | 65 ± 4*†‡ | 85 ± 3† | 93 ± 3*† | 94 ± 3*† |
| Heart rate, beats/min | 61 ± 2 | 61 ± 2 | 61 ± 2 | 62 ± 2 | 62 ± 2 | 62 ± 2 |
| Cardiac output, l/min | 5.4 ± 0.4 | 5.7 ± 0.4 | 5.8 ± 0.4* | 5.9 ± 0.3* | 6.0 ± 0.3* | 5.9 ± 0.3* |
| 20% MVC (l-NMMA + Ketorolac) | ||||||
| Mean arterial pressure, mmHg | 88 ± 4 | 95 ± 4* | 95 ± 4* | 99 ± 4* | 100 ± 4*†‡ | 100 ± 5*†‡ |
| Brachial artery pressure, mmHg | 87 ± 2† | 91 ± 2† | 64 ± 4*‡ | 85 ± 3† | 93 ± 2† | 94 ± 3† |
| Heart rate, beats/min | 62 ± 2 | 64 ± 2 | 64 ± 2 | 64 ± 2 | 64 ± 2 | 64 ± 2 |
| Cardiac output, l/min | 5.4 ± 0.3 | 5.7 ± 0.3 | 5.7 ± 0.4 | 6.0 ± 0.3* | 6.0 ± 0.3* | 5.9 ± 0.3* |
Values are means ± SE.
*
P < 0.05 vs. baseline.
†
P < 0.05 vs. nadir.
‡
P < 0.05 vs. exercise (control).