Table 3.
Associations between TP53 and XRCC1 polymorphisms and tumor characteristics
| Variables | TP53 | XRCC1 | ||||||
| PIN 3 | Arg72Pro | Arg194Trp | Arg399Gln | |||||
| 1.1 | 1.2 + 2.2 | Arg/Arg | Arg/Pro + Pro/Pro | Arg/Arg | Arg/Trp + Trp/Trp | Arg/Arg | Arg/Gln + Gln/Gln | |
| Tumor size (n = 92) | ||||||||
| ≤ 2 cm | 34 | 20 | 18 | 36 | 51 | 7 | 29 | 29 |
| > 2 cm | 25 | 13 | 15 | 23 | 34 | 6 | 23 | 17 |
| OR (95% CI) | 1.00 (ref.) | 0.88 (0.37 – 2.11) | 1.00 (ref.) | 0.77 (0.32 – 1.82) | 1.00 (ref.) | 1.29 (0.40 – 4.16) | 1.00 (ref.) | 0.79 (0.33 – 1.66) |
| ap | 0.828 | 0.660 | 0.765 | 0.539 | ||||
| EG (n = 104) | ||||||||
| I / II | 55 | 27 | 28 | 54 | 78 | 9 | 48 | 39 |
| III | 12 | 10 | 8 | 14 | 15 | 7 | 13 | 9 |
| OR (95% CI) | 1.00 (ref.) | 1.70 (0.65 – 4.42) | 1.00 (ref.) | 0.91 (0.34 – 2.42) | 1.00 (ref.) | 4.04 (1.30 – 12.35) | 1.00 (ref.) | 0.85 (0.33 – 2.20) |
| ap | 0.320 | 1.000 | 0.018 | 0.813 | ||||
| Lymph node (n = 88) | ||||||||
| Negative | 28 | 15 | 15 | 28 | 37 | 8 | 28 | 17 |
| Positive | 28 | 17 | 15 | 30 | 42 | 6 | 23 | 25 |
| OR (95% CI) | 1.00 (ref.) | 1.13 (0.47 – 2.70) | 1.00 (ref.) | 1.07 (0.44 – 2.59) | 1.00 (ref.) | 0.66 (0.21 – 2.08) | 1.00 (ref.) | 1.79 (0.78 – 4.09) |
| ap | 0.827 | 1.000 | 0.568 | 0.212 | ||||
| ER (n = 72) | ||||||||
| Positive | 33 | 15 | 20 | 28 | 43 | 8 | 26 | 25 |
| Negative | 16 | 8 | 9 | 15 | 21 | 4 | 16 | 9 |
| OR (95% CI) | 1.00 (ref.) | 1.10 (0.39 – 3.13) | 1.00 (ref.) | 1.19 (0.43 – 3.25) | 1.00 (ref.) | 1.02 (0.28 – 3.79) | 1.00 (ref.) | 0.58 (0.22 – 1.56) |
| ap | 1.000 | 0.802 | 1.000 | 0.332 | ||||
| PR (n = 73) | ||||||||
| Positive | 32 | 15 | 18 | 29 | 43 | 7 | 25 | 25 |
| Negative | 18 | 8 | 11 | 15 | 22 | 5 | 17 | 10 |
| OR (95% CI) | 1.00 (ref.) | 0.95 (0.34 – 2.67) | 1.00 (ref.) | 0.85 (0.32 – 2.24) | 1.00 (ref.) | 1.40 (0.40 – 4.91) | 1.00 (ref.) | 0.59 (0.23 – 1.53) |
| ap | 1.000 | 0,805 | 0.744 | 0.341 | ||||
| HER2 (n = 63) | ||||||||
| Negative | 27 | 7 | 17 | 17 | 32 | 4 | 19 | 17 |
| Positive | 17 | 12 | 9 | 20 | 25 | 7 | 20 | 12 |
| OR (95% CI) | 1.00 (ref.) | 2.72 (0.89 – 8.28) | 1.00 (ref.) | 2.22 (0.79 – 6.26) | 1.00 (ref.) | 2.24 (0.59 – 8.52) | 1.00 (ref.) | 0.67 (0.25 – 1.77) |
| ap | 0.100 | 0.199 | 0.325 | 0.468 | ||||
ER = estrogen receptor; PR = progesterone receptor; ap = Fisher's exact test (common homozygote x heterozygote + rare homozygote); OR = odds ratio; CI = confidence interval.