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. 2011 Jul 5;6(7):e21876. doi: 10.1371/journal.pone.0021876

Figure 12. Enrichment of Notch receptor near the cell surface results in F-actin enrichment also near the cell surface.

Figure 12

A. F-actin levels in S2 cells expressing Notch (S2-Notch cells) and S2 cells expressing ligand Delta (S2-Delta cells) that were not mixed together. B. F-actin levels in S2-Notch and S2-Delta cells brought together by Notch and Delta binding. Notch and Delta binding results in Notch receptor enrichment (clustering) at contact points between the two cell types (Delta does not show this response [27]). Notch enrichment diminishes over time, possibly due to production of Nintra/NICD or reduction in Notch synthesis.