FIGURE 1. Production of several virulence factors in H. pylori (A) and translocation and phosphorylation of CagA (B).
Total lysates of different H. pylori and their corresponding ΔalpAB mutants were separated on 8–12% SDS gels, blotted to nitrocellulose, and incubated with specific antibodies that recognize various H. pylori virulence factors (A). Total lysates of AGS cells co-cultured with H. pylori were separated on 8% SDS gels, blotted to nitrocellulose, and incubated with the phosphotyrosine-specific monoclonal antibody PY99 (B). Typical gels for four parental strains and their ΔalpAB mutants (clone 1) are presented.