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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Am J Obstet Gynecol. 2011 Mar 31;204(6):524.e1–524.e4. doi: 10.1016/j.ajog.2011.01.056

Table 1.

Pharmacokinetic parameters for oseltamivir phosphate prodrug and oseltamivir carboxylate in plasma and breast milk.

OSELTAMIVIR PHOSPHATE OSELTAMIVIR CARBOXYLATE
Plasma Breast milk Plasma Breast milk
Cmax (ng/mL) 70.1 ± 72.6 26.9 ± 14.0 224.3 ± 40.5 41.9 ± 21.0
Tmax (hour) 2.6 ± 2.4 3.4 ± 2.2 4.6 ± 1.5 18.9 ± 6.4
T1/2 (hour) 4.2 ± 2.4 4.2 ± 1.2 16.1 ± 8.0 n/a
AUC0–24 h (ng·h/mL) 155.6 ± 57.9 143.4 ± 73.4 2611.7 ± 349.0 569 ± 405.8

Data reported as mean ± SD