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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Psychoneuroendocrinology. 2011 Mar 15;36(8):1164–1174. doi: 10.1016/j.psyneuen.2011.02.008

Figure 1. Effects of CIC stress on LPS-induced activation of the HPA axis and levels of pro-inflammatory cytokines in plasma.

Figure 1

Rats were sacrificed 2h or 5h after injection of LPS (0.2mg/kg, IP) or an equal volume of saline vehicle. Data from both time points in the vehicle-injected animals were pooled. Measures of corticosterone (panel A, n = 11–14), ACTH (panel B, n = 12–15), IL1β (panel C, n = 11–15) and IL6 (panel D, n = 5–10) were performed on plasma samples derived from trunk blood. * significantly different from Vehicle control in the same treatment group; + significantly different comparing NS and CIC (Chronic Intermittent Cold) at the same time point; all comparisons by Newman-Keuls post-test at p<0.05.