Table 1. Reproducibility and Reliability Results.
Results of test-retest statistical analyses for LCModel data without partial volume correction (“LCModel”), LCModel data after partial volume correction (“corrected”), and gray matter (“GM”) and white matter (“WM”) estimates of concentrations. Percent of total variance (“%”) for each variance component appears in the adjacent column to the right.
| Metabolite | Mean | Variance | CV | ICC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject | % | Scan | % | Voxel | % | error | % | Total | ||||
| NAA | ||||||||||||
| LCmodel | 17.51 | 0.612 | 25.3 | 0.021 | 0.9 | 0.842 | 34.9 | 0.941 | 38.9 | 2.416 | 0.06 | 0.60 |
| corrected | 16.45 | 0.446 | 10.5 | 0.019 | 0.4 | 2.874 | 67.8 | 0.899 | 21.2 | 4.238 | 0.06 | 0.78 |
| GM | 19.54 | 0.886 | 76.3 | 0.008 | 0.7 | 0.267 | 23.0 | 1.161 | 0.03 | 0.76 | ||
| WM | 14.23 | 0.627 | 83.4 | 0.006 | 0.8 | 0.119 | 15.8 | 0.752 | 0.02 | 0.83 | ||
| tNAA | ||||||||||||
| LCmodel | 19.63 | 0.640 | 28.7 | 0.018 | 0.8 | 0.739 | 33.1 | 0.836 | 37.4 | 2.233 | 0.05 | 0.62 |
| corrected | 18.37 | 0.476 | 21.7 | 0.016 | 0.7 | 0.936 | 42.7 | 0.765 | 34.9 | 2.193 | 0.05 | 0.64 |
| GM | 19.50 | 0.521 | 65.1 | 0.026 | 3.3 | 0.253 | 31.6 | 0.800 | 0.03 | 0.65 | ||
| WM | 17.48 | 0.727 | 89.5 | 0.001 | 0.1 | 0.084 | 10.3 | 0.812 | 0.02 | 0.90 | ||
| Cr | ||||||||||||
| LCmodel | 12.42 | 0.316 | 9.6 | 0.007 | 0.2 | 2.446 | 74.3 | 0.523 | 15.9 | 3.292 | 0.06 | 0.84 |
| corrected | 12.88 | 0.609 | 8.8 | 0.008 | 0.1 | 5.668 | 81.4 | 0.675 | 9.7 | 6.960 | 0.06 | 0.90 |
| GM | 17.52 | 1.373 | 82.0 | 0.062 | 3.7 | 0.239 | 14.3 | 1.674 | 0.03 | 0.82 | ||
| WM | 9.67 | 0.230 | 82.1 | 0.000 | 0.0 | 0.050 | 17.9 | 0.280 | 0.02 | 0.82 | ||
| Cho | ||||||||||||
| LCmodel | 3.58 | 0.040 | 14.5 | 0.002 | 0.7 | 0.179 | 64.9 | 0.055 | 19.9 | 0.276 | 0.07 | 0.79 |
| corrected | 3.21 | 0.038 | 17.7 | 0.002 | 0.9 | 0.131 | 60.9 | 0.044 | 20.5 | 0.215 | 0.07 | 0.79 |
| GM | 3.27 | 0.061 | 74.4 | 0.004 | 4.9 | 0.017 | 20.7 | 0.082 | 0.04 | 0.75 | ||
| WM | 3.17 | 0.058 | 90.6 | 0.000 | 0.0 | 0.006 | 9.4 | 0.064 | 0.02 | 0.90 | ||
| mI | ||||||||||||
| LCmodel | 12.08 | 0.750 | 13.2 | 0.033 | 0.6 | 3.296 | 58.1 | 1.594 | 28.1 | 5.673 | 0.11 | 0.71 |
| corrected | 10.64 | 0.820 | 12.5 | 0.028 | 0.4 | 4.395 | 67.1 | 1.304 | 19.9 | 6.547 | 0.11 | 0.80 |
| GM | 14.48 | 0.685 | 49.7 | 0.159 | 11.5 | 0.533 | 38.7 | 1.377 | 0.06 | 0.50 | ||
| WM | 7.96 | 1.084 | 93.1 | 0.000 | 0.0 | 0.080 | 6.9 | 1.164 | 0.04 | 0.93 | ||
| Glu | ||||||||||||
| LCmodel | 16.77 | 0.324 | 2.9 | 0.004 | 0.0 | 7.918 | 70.4 | 2.995 | 26.6 | 11.241 | 0.10 | 0.73 |
| corrected | 15.49 | 0.431 | 2.8 | 0.001 | 0.0 | 12.071 | 78.7 | 2.836 | 18.5 | 15.339 | 0.11 | 0.82 |
| GM | 22.06 | 1.286 | 54.1 | 0.000 | 0.0 | 1.093 | 45.9 | 2.379 | 0.05 | 0.54 | ||
| WM | 10.49 | 0.097 | 21.7 | 0.000 | 0.0 | 0.349 | 78.3 | 0.446 | 0.06 | 0.22 | ||
| Glx | ||||||||||||
| LCmodel | 20.67 | 0.765 | 3.0 | 0.126 | 0.5 | 17.824 | 69.2 | 7.052 | 27.4 | 25.767 | 0.13 | 0.72 |
| corrected | 19.17 | 1.305 | 4.0 | 0.095 | 0.3 | 25.157 | 76.2 | 6.476 | 19.6 | 33.033 | 0.13 | 0.80 |
| GM | 28.47 | 3.380 | 67.9 | 0.000 | 0.0 | 1.595 | 32.1 | 4.975 | 0.04 | 0.68 | ||
| WM | 11.93 | 0.768 | 45.0 | 0.222 | 13.0 | 0.717 | 42.0 | 1.707 | 0.08 | 0.45 | ||