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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Biomaterials. 2011 Sep;32(26):6291–6301. doi: 10.1016/j.biomaterials.2011.05.024

Figure 3. PEG-MNP biodistribution time course in primary organs of nanoparticle elimination (n=9).

Figure 3

In agreement with data in Figure 2, the spleen possesses enhanced biodistribution of PEG-MNPs throughout the time course. MNPs appear to continue to accumulate in the spleen during plasma clearance – tissue concentrations at later time points are substantially higher than that observed for D or PEG-MNPs at 1 hr. An interesting find from the data is the reduced level of MNP distribution in liver throughout the course of the run – tissue MNP concentrations remain significantly below those observed for D at 1 hour (Figure 2). Similar (to liver) levels of MNPs were measured in the lung and only minimal levels were observed in the kidney.