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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Biomaterials. 2011 Sep;32(26):6291–6301. doi: 10.1016/j.biomaterials.2011.05.024

Figure 7. Histological analysis of magnetically targeted (A) and non-targeted (B) tumor and normal brain tissues.

Figure 7

Images confirm greater retention of MNPs at the tumor site (denser cell regions) after magnetic targeting, evidenced by the Prussian Blue stained iron deposits observable in tumor tissues. Heterogeneous distribution is observed, likely due to the variably compromised BTB characteristic of a brain tumor. Conversely, little MNP accumulation is detectable in tumors not subject to magnetic targeting. Data suggest that magnetic targeting both captures and helps better retain MNPs at the tumor lesion, with limited passive contribution to retention. Distribution is not observed in the normal brain, with and without targeting, even at tumor-brain boundaries. Normal brain results further confirm tumor selectivity observed in MR images in Figure 5 and ESR data in Figure 6.