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Key physical and pharmacokinetic properties of D & PEG-MNPs [16]
| MNP Property | D | D5 | D20 |
|---|---|---|---|
| Hydrodynamic diameter (nm) | 104.1 ± 2.3 | 142.2 ± 5.6 | 168.5 ± 1.4 |
| [PEG] (nmol/mg Fe) | - | 4.27 ± 0.68 | 1.14 ± 0.25 |
| NH2 groups occupied by PEG (%) | - | 1.45 | 0.39 |
| T1/2,plasma (hr) | 0.12 | 7.29 | 11.75 |
| AUC0-∞,plasma (µg Fe*hr/mL) | 12 | 1182 | 1801 |
