Table 3b.
CTCAE grade ≥3 abnormal laboratory findings/vital signs reported by any patient
| Patients with grade ≥3 abnormal laboratory findings/vital signs, N (%) | |||||
|---|---|---|---|---|---|
| AZD4877 dose | |||||
| 10 mg (N = 3) | 15 mg (N = 3) | 20 mg (N = 6) | 25 mg (N = 6) | Total (N = 18) | |
| Any grade ≥3 finding/vital sign | 1 (33) | 1 (33) | 4 (67) | 6 (100) | 12 (67) |
| Neutropenia | 1 (33) | 1 (33) | 3 (50) | 5 (83) | 10 (56) |
| Leukopenia | 0 | 0 | 3 (50) | 5 (83) | 8 (44) |
| Lymphopenia | 0 | 0 | 0 | 1 (17) | 1 (6) |
| Thrombocytopenia | 0 | 0 | 0 | 1 (17) | 1 (6) |
| Blood sodium decreased | 0 | 0 | 1 (17) | 0 | 1 (6) |
| Hemoglobin decreased | 0 | 0 | 0 | 1 (17) | 1 (6) |
| Lymphocyte count decreased | 0 | 0 | 0 | 1 (17) | 1 (6) |
| Weight decreased | 0 | 0 | 1 (17) | 0 | 1 (6) |
Cut-off value for values for defining grade ≥3 abnormal laboratory finding: neutropenia <1.0 × 109/L; leukopenia <2.0 × 109/L; lymphopenia: <0.5 × 109/L; thrombocytopenia: <50.0 × 109/L; blood sodium decreased: <130 mmol/L; hemoglobin decreased: <8.0 g/dL; lymphocyte count decreased: <0.5 × 109/L; weight decreased: ≥20% from baseline.