Table 3c.
Selected laboratory hematology variables at baseline and during cycle 1
| AZD4877 dose | |||||
|---|---|---|---|---|---|
| Parameter, mean (SD) | 10 mg (N = 3) | 15 mg (N = 3) | 20 mg (N = 6) | 25 mg (N = 6) | Total (N = 18) |
| White blood cell count, 103/µL | |||||
| Baseline | 4.28 (0.91) | 6.95 (1.46) | 6.03 (3.08) | 4.94 (1.28) | 5.53 (2.11) |
| Cycle 1, Day 8 | 4.13 (0.63) | 5.50 (1.48) | 2.97 (1.06) | 3.01 (0.99) | 3.60 (1.37) |
| Cycle 1, Day 15 | 3.59 (0.69) | 4.66 (2.19) | 2.82 (1.20) | 1.58 (0.57) | 2.84 (1.55) |
| Cycle 1, Day 22 | 4.09 (0.66) | 4.53 (1.70) | 2.64 (0.69) | 2.73 (0.68) | 3.23 (1.14) |
| Platelet count, 103/µL | |||||
| Baseline | 233.3 (69.3) | 242.3 (21.5) | 279.2 (40.2) | 276.5 (71.7) | 264.5 (54.7) |
| Cycle 1, Day 8 | 227.3 (36.7) | 229.0 (35.9) | 245.7 (45.5) | 246.5 (99.7) | 240.1 (62.6) |
| Cycle 1, Day 15 | 203.3 (46.5) | 217.0 (6.1) | 265.2 (79.5) | 184.5 (85.1) | 219.9 (73.9) |
| Cycle 1, Day 22 | 205.0 (54.0) | 232.0 (7.9) | 262.2 (48.0) | 308.7 (117.3) | 263.1 (81.1) |
| Total ANC, 103/µL | |||||
| Baseline | 2.48 (0.38) | 4.36 (0.87) | 4.34 (2.95) | 3.39 (1.38) | 3.72 (1.94) |
| Cycle 1, Day 8 | 2.00 (0.37) | 3.23 (1.26) | 1.81 (0.99) | 2.00 (0.97) | 2.14 (1.01) |
| Cycle 1, Day 15 | 1.25 (0.27) | 2.33 (1.62) | 1.49 (0.82) | 0.57 (0.50) | 1.28 (0.99) |
| Cycle 1, Day 22 | 1.68 (0.35) | 2.30 (1.50) | 1.25 (0.69) | 1.41 (0.48) | 1.55 (0.79) |
ANC=absolute neutrophil count.