Table 1.
Fold maximum stimulation (Diab/Cont)
| Heart/Aorta | Inoculation Site | |
|---|---|---|
| TNF-alpha | 2.61 | 2.31 |
| MCP-1 | 1.51 | 1.91 |
| ICAM-1 | 1.51 | 2.31 |
| MIP-1 alpha | 2.71 | 1.3 |
The inflammatory response to subcutaneous injection of LPS is greater in diabetic than normoglycemic animals at both the site of inoculation and at a distant site, cardiovascular tissue. LPS was inoculated into the scalp and RNA was extracted from the site of inoculation and the heart/aorta at 1.5, 6 and 24 hours after inoculation. The fold difference between diabetic and normal mice at the time of peak expression is shown.
1
indicates a significant difference between diabetic and normoglycemic groups (P<0.05)