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. Author manuscript; available in PMC: 2011 Jul 6.
Published in final edited form as: Leukemia. 2010 Jun 24;24(9):1545–1554. doi: 10.1038/leu.2010.143

Figure 1. Mouse model for studying BCR-ABL leukemia.

Figure 1

There are three major types of mouse models of CML. a. BCR-ABL transgenic model. Inducible expression of BCR-ABL controlled by tTA tet-off system in BCR-ABL transgenic mouse. b. Retroviral bone marrow transduction/transplantation model. Bone marrow cells from 5-FU treated donor mice are transduced with BCR-ABL retrovirus, cultured in the presence of cytokines, and then transplanted into lethally irradiated syngeneic recipient mice. c. Human xenograft NOD/SCID mouse model. Bone marrow or peripheral blood cells from CML patients are purified for CD34+ cells, and then the cells are transplanted into NOD/SCID mice.