Table 1.
Chronic-phase CML | Blast-crisis CML | |
---|---|---|
LSCs | BCR-ABL transformed HSCs | BCR-ABL transformed GMPs |
Human LSC markers | CD34+CD38−CD90+Lin− | CD34+CD38+Lin− |
Mouse LSC markers | Lin−c-Kit+Sca-1+ | Lin−c-Kit+Sca-1−FcγR+ |
Activation of Wnt/ β-catenin | Yes | Yes |
Other oncogenic mutations | Unclear | Yes |
Treatment | Imatinib | Chemotherapy or BMT |