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. 2011 Feb 25;39(12):4949–4960. doi: 10.1093/nar/gkq1326

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Distribution of histone modifications at rDNA. (A) Patterns of histone modifications at rDNA in K562 cells. A schematic representation of the human rDNA repeat is shown above the ChIP-seq plots. UCE: upstream control element; CPE: core promoter element; ETS: external transcribed spacer; ITS: internal transcribed spacer; SAL box: transcription terminator region with SAL repeats; SP: spacer promoter. The coding region spans ∼0–13.3 kb of the rDNA repeat, with the remainder made up by the non-coding IGS. Shown below the rDNA repeat are patterns of histone modifications at rDNA in K562 cells as determined by ChIP-seq. Plots for HUVEC, H1-hESC and NHEK are presented in Supplementary Figure S2. (B) Correlation heatmap of pairwise comparisons between median signals for all histone modifications at rDNA in K562 cells. Heatmaps for HUVEC, H1-hESC and NHEK are presented in Supplementary Figure S4. (C) Normalized tag density for histone modifications. Normalized tag density was determined by dividing the average intensity of the three highest peaks at rDNA by the average intensity of the 100 highest peaks along chromosome 13.