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. 2011 Feb 23;39(12):5067–5081. doi: 10.1093/nar/gkr088

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — A model for domain-guided localization of SBP75/LEDGF in nuclear compartments. Three domains in SBP75/LEDGF (PWWP, NRD and SRD) are likely to be involved in the localization. PWWP exerts a strong tethering effect that directs the protein, for the most part, to condensed chromatin territory, probably through interaction with nucleosomes. NRD may bind to any DNA in a structure-independent manner, whereas SRD binds selectively to negative supercoils generated around the transcription factory, thus recruiting IBD-bound proteins (data not shown) for preferential targeting toward active transcription units. Although it is not indicated in the scheme, PWWP in the targeted complex may also interact with nearby nucleosomes.