Table 3.

Association between obesity, hsCRP, and subclinical atherosclerosis -MESA (2000–2002).

	Odds Ratio		β-coefficient
	CAC>0	CIMT (>75th percentile)	CAC score (log CAC + 1)	Maximum CIMT (mm)
Total Population Age, gender, race adjusted
Non-obese/hsCRP<2	1 (ref)	1 (ref)	0 (ref)	0 (ref)
Non-obese/hsCRP≥2	1.18 (1.00 – 1.40)	1.34 (1.11 – 1.62)	0.12 (−0.05 – 0.29)	0.27 (0.15 – 0.38)
Obese/hsCRP<2	1.51 (1.29 – 1.76)	1.63 (1.36 – 1.95)	0.48 (0.33 – 0.64)	0.48 (0.37 – 0.58)
Obese/hsCRP≥2	1.51 (1.32 – 1.74)	2.17 (1.86 – 2.54)	0.45 (0.31 – 0.59)	0.66 (0.57 – 0.76)
MESA JUPITER population* Age, gender, race adjusted
Non-obese/hsCRP<2	1 (ref)	1 (ref)	0 (ref)	0 (ref)
Non-obese/hsCRP≥2	1.11 (0.85 – 1.47)	1.35 (0.99 – 1.83)	0.10 (−0.20 – 0.40)	0.37 (0.18 – 0.55)
Obese/hsCRP<2	1.68 (1.26 – 2.22)	1.43 (1.05 – 1.95)	0.63 (0.32 – 0.93)	0.50 (0.31 – 0.69)
Obese/hsCRP≥2	1.28 (1.00 – 1.64)	2.33 (1.78 – 3.05)	0.47 (0.20 – 0.74)	0.68 (0.51 – 0.85)
MESA JUPITER population* Fully adjusted**
Non-obese/hsCRP<2	1 (ref)	1 (ref)	0 (ref)	0 (ref)
Non-obese/hsCRP≥2	1.04 (0.79 – 1.38)	1.31 (0.96 – 1.80)	0.01 (−0.28 – 0.31)	0.34 (0.15 – 0.52)
Obese/hsCRP<2	1.44 (1.07 – 1.94)	1.28 (0.93 – 1.77)	0.44 (0.13 – 0.75)	0.40 (0.21 – 0.59)
Obese/hsCRP≥2	1.01 (0.78 – 1.31)	2.10 (1.58 – 2.80)	0.20 (−0.08 – 0.48)	0.54 (0.37 – 0.72)

^*MESA JUPITER population (N=2,083): Men age ≥50 and women ≥60 with LDL-C <130 mg/dL, not on lipid-lowering therapy, without diabetes, triglycerides ≤500 mg/dL, and creatinine ≤2 mg/dL

^**Fully adjusted model: Adjusted for age, gender, race, systolic blood pressure, diastolic blood pressure, smoking, LDL-C, HDL-C, triglycerides, anti-hypertensive medications

β-coefficient should be interpreted as the absolute difference between each category and the reference category.