. Author manuscript; available in PMC: 2012 Feb 1.

Published in final edited form as: J Clin Psychopharmacol. 2011 Feb;31(1):22–30. doi: 10.1097/JCP.0b013e31820465fa

Table 3.

Multilevel Regression Results for the Number of Heavy Drinking Days by Medication Group, Age of Alcohol Dependence Onset, and Genotype Group

Predictor Variables	b	SE	t	p
Block 1
Sex	0.817	0.463	1.764	0.080
Age	−0.078	0.020	−3.836	0.000
Short Index of Problems Score	0.018	0.024	0.754	0.452
Lifetime Major Depression Diagnosis	1.017	0.424	2.401	0.018
Baseline Heavy Drinking Days	1.578	0.620	2.543	0.013
5-HTTLPR Genotype	−0.067	0.405	−0.167	0.868
Medication Group^a	−0.351	0.442	−0.795	0.428
Age of Onset of Alcohol Dependence (AD)^a	0.434	0.682	0.637	0.525
AD Onset × Group	−0.795	0.786	−1.011	0.315
Block 2^b
Study Week	0.066	0.043	1.554	0.123
Medication Group × Genotype	−3.716	1.524	−2.438	0.016
AD Onset × Genotype	−5.220	1.460	−3.576	0.001
Study Week × Medication Group	0.281	0.096	2.934	0.004
Study Week × Genotype	0.137	0.078	1.766	0.079
Study Week × AD Onset	0.330	0.088	3.748	<0.001
AD Onset × Genotype × Medication Group	8.402	2.116	3.972	<0.001
Study Week × Medication Group × Genotype	−0.356	0.125	−2.850	0.006
Study Week × AD Onset × Medication Group	−0.683	0.125	−5.479	<0.001
Study Week × AD Onset × Genotype	−0.402	0.128	−3.142	0.003
Study Week × AD Onset × Genotype × Medication Group	0.647	0.179	3.608	0.001

Medication Group is a conditional effect for individuals who have late-onset alcohol dependence (AD); Age of Onset of AD is a conditional effect for individuals who are in the sertraline group.

The 2-way and 3-way interactions in block 2 are conditional effects for individuals coded zero on the predictor(s) not involved in the interaction (but included in the 4-way interaction).