Table 1. Absolute cerebral NIRS parameters measured at baseline and after induction of hypoxia or hypercapnia, in folate-deficient (FD) and control rats at 10 and 20 weeks.
| Hypoxia—week 10 | [HbO2] (μmol/L) | [Hb] (μmol/L) | [HbT] (μmol/L) | StO2 (%) | SaO2 (%) |
|---|---|---|---|---|---|
| Baseline | |||||
| Control | 54 (6) | 33 (1) | 87 (7) | 62 (2) | 92 (2) |
| FD | 37 (3) | 35 (3) | 73 (1) | 51 (4) | 94 (6) |
| |
Δ[HbO2] (μmol/L) |
Δ[Hb] (μmol/L) |
Δ[HbT] (μmol/L) |
ΔStO2 (%) |
ΔSaO2 (%) |
| Hypoxia | |||||
| Control | −17 (1) | 18 (1) | 0.7 (4) | −20 (2) | −19 (2) |
| FD | −13 (3) | 13 (3) | 0.1 (3) | −17 (4) | −19 (2) |
|
Hypoxia—week 20 |
[HbO2] (μmol/L) |
[Hb] (μmol/L) |
[HbT] (μmol/L) |
StO2 (%) |
SaO2(%) |
| Baseline | |||||
| Control | 62 (5) | 33 (1) | 95 (6) | 65 (2) | 95 (3) |
| FD | 40 (4) | 33 (1) | 72 (4) | 54 (3) | 96 (5) |
| |
Δ[HbO2] (μmol/L) |
Δ[Hb] (μmol/L) |
Δ[HbT] (μmol/L) |
ΔStO2 (%) |
ΔSaO2 (%) |
| Hypoxia | |||||
| Control | −12 (1) | 12 (1) | 0.7 (1) | −12 (1) | −14 (1) |
| FD | −8 (1) | 8 (1) | 0.1 (3) | −11 (3) | −16 (2) |
|
Hypercapnia—week 20 |
[HbO2] (μmol/L) |
[Hb] (μmol/L) |
[HbT] (μmol/L) |
StO2 (%) |
SaO2 (%) |
| Baseline | |||||
| Control | 59 (2) | 33 (2) | 92 (4) | 65 (1) | 95 (4) |
| FD | 41 (4) | 32 (1) | 72 (4) | 56 (2) | 96 (4) |
| |
Δ[HbO2] (μmol/L) |
Δ[Hb] (μmol/L) |
Δ[HbT] (μmol/L) |
ΔStO2 (%) |
ΔSaO2 (%) |
| Hypercapnia | |||||
| Control | 5.7 (7) | −2.8 (4) | 2.9 (3) | 4.0 (4) | 0.4 (1) |
| FD | 4.0 (5) | −2.3 (3) | 1.7 (4) | 4.0 (1) | 0.5 (2) |
[Hb], tissue concentration of deoxy-hemoglobin; [HbO2], tissue concentration of oxy-hemoglobin; [HbT], total hemoglobin concentration in tissue; NIRS, near-infrared spectroscopy; SaO2, arterial oxygen saturation; StO2, oxygen saturation of hemoglobin in brain tissue.
Values represent mean (s.e.m.).