The changes in IGF1R expression (A), cell proliferation (B), cell-cycle distribution (C) and cell-apoptosis rate (D) were examined as described in the Experimental section in UM1 cells that were treated with miR-7 mimic, control mimic, IGF1R-specific siRNA or control siRNA, and UM2 cells that were treated with anti-miR-7 PNA or scrambled LNA. Results shown in (B) and (D) are means ± S.D.; all results are representative of at least three independent experiments. *P < 0.05. ACTB, β-actin.