Table 3.
Association of ovarian cancer with relative leukocyte telomere length for selected variables
| Telomere status | Controls n (%) | Cases n (%) | OR† (95% CI) | P value |
|---|---|---|---|---|
| Well/moderate tumor grade of differentiation | ||||
| Shorta | 50 (50.0) | 8 (40.0) | 0.82 (0.29–2.28) | 0.696 |
| Long | 50 (50.0) | 12 (60.0) | 1.0 (ref) | |
| Poor tumor grade of differentiation | ||||
| Short | 50 (50.0) | 33 (82.5) | 4.89 (1.93–12.34) | <0.001 |
| Long | 50 (50.0) | 7 (17.5) | 1.0 (ref) | |
| Never used HRT | ||||
| Short | 39 (50.0) | 55 (73.3) | 2.70 (1.36–5.38) | 0.005 |
| Long | 39 (50.0) | 20 (26.7) | 1.0 (ref) | |
| Ever used HRT | ||||
| Short | 10 (50.0) | 15 (65.2) | 2.25 (0.55–9.15) | 0.259 |
| Long | 10 (50.0) | 8 (34.8) | 1.0 (ref) | |
| LOCb ≤ 419 | ||||
| Short | 30 (49.2) | 32 (58.2) | 1.49 (0.70–3.16) | 0.298 |
| Long | 31 (50.8) | 23 (41.8) | 1.0 (ref) | |
| LOC > 419 | ||||
| Short | 16 (51.6) | 31 (77.5) | 4.45 (1.42–13.94) | 0.010 |
| Long | 15 (48.4) | 9 (22.5) | 1.0 (ref) | |
†
Odds ratios (95% confidence intervals) and corresponding P values adjusted for age; n = number of subjects
a
Telomere length dichotomized at the median based on the distribution in the controls
b
The first and second tertiles of lifetime ovulatory cycles were combined