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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Bone. 2011 Apr 3;48(6):1362–1369. doi: 10.1016/j.bone.2011.03.773

Figure 3. Impaired IVD in OPG−/− mice.

Figure 3

(A) Histomoprhometric assessment of newly formed bony tissues in endplate of 12-, 20- and 28-week-old WT and OPG−/− mice. Values are the mean ± SD of 3 mice. Three sections per mouse were analyzed. (B) The expression levels of aggrecan, mmp13 and Col10 mRNA in RNA extracted from IVD and endplate cartilages of 12-, 20- and 28-week-old WT and OPG−/− mice. The values are the mean ± SD of 3 independent experiments. *p< 0.05 vs. WT group. (C) TUNEL staining of IVDs of 28-week-old OPG−/− mice and WT littermates. Left photos are toludine blue stained sections and the right photos are the TUNEL stained adjacent sections. Apoptotic cells were indicated by yellow arrows.