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. Author manuscript; available in PMC: 2012 Jun 27.
Published in final edited form as: J Chem Inf Model. 2011 May 13;51(6):1393–1404. doi: 10.1021/ci200077t

Figure 4.

Figure 4

Hanes plots of inhibition of the binding of [3H]HB to tubulin by (A) eribulin, (B) vincristine, or (C) D10. Each 0.3 mL reaction mixture contained 2.5 μM tubulin and the indicated concentrations of [3H]HB and inhibitor. Reaction mixtures were incubated 30 min. (A) Reaction mixtures contained eribulin:○, none; Δ, 1 μM;▽, 2 μM; □, 3 μM; ◇, 4 μM. (B) Reaction mixtures contained vincristine:○, none; Δ, 3 μM;▽, 9 μM; □, 12 μM. (C) Reaction mixtures contained D10: o, none; Δ, 2 μM; ▽, 3 μM; □, 4 μM; ◇, 6 μM.